A study published in the British Journal of Nutrition investigated the effect of astaxanthin on phospholipid hydroperoxides, which are known to accumulate abnormally in the red blood cells of people with dementia. The study included 30 healthy volunteers between the ages of 50 and 69 years who were randomly assigned to receive either 6 mg or 12 mg of astaxanthin or 0 mg placebo per day for 12 weeks. The results revealed that after 12 weeks of treatment, levels of phospholipid hydroperoxides were significantly lower in erythrocytes following astaxanthin supplementation with reductions in the order of about 40 and 50 percent in the 6 and 12 mg groups, respectively, compared with no significant change in the placebo group. These findings suggest that supplementation with astaxanthin improved erythrocyte antioxidant status and decreased phospholipid hydroperoxides levels, which may help prevent dementia.

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